[DonVoigt]

GT,
2 different chemicals and two different purposes.
Superglue is an "adhesive", it works best with a porous surface to adhere to and is not very strong against "shearing" force- pulling yes. It may have some effect as a locking agent. Superglue is not flexible when cured.

Loctite is a hardening plastic/polymer type compound , it fills spaces and turns to a solid- but does not "stick" anything together, it only works by friction from the very tight fit it causes and the nooks and crannies it fills and then solidifies into a single piece of plastic. It remains flexible, which helps with its removal.

Nylon lock nuts or Nylocs are good once, if they are removed they lose tension as they have been deformed in the first installation.

Safety wire is very good, but Not universally applicable, and fallible also. One might think it "best" as it is what is used on airplanes, where a "loose nut" is fatal.

This is a pretty basic and over simplification of the two compounds and how they work.

JMHO as an "ex" chemist and long time 'smith.