Holster Wear on Grips?

I've sometimes wondered what effect leather tanning chemicals might have had on the finish of a pistol holstered for a long period. I recall an old article in a hot rod magazine commenting about the smell seats in California cars which had been reupholstered with Mexican leather got if they were rained on. It was believed the leather had been "tanned" in horse urine; which was highly acidic. Could tanning chemicals (regardless of origin) "leach out" of a holster over time; and degrade a pistol's finish?